MAME revolves around the antics of Mame Dennis, a fun-loving, wealthy eccentric with a flair for life and a razor sharp wit. Her life is suddenly changed when she becomes the guardian of her late brother's only child, Patrick.
Her adventures take you from the speakeasies of the Roaring 20's to the Great Depression following the great stock market crash. Mame is rescued by a wealthy Southern plantation owner, marries and is widowed suddenly, and through it all, manages to keep things under control. With some help from her dearest friend, Vera Charles, Mame keeps things at 3 Beekman Place a rousing free-for-all.